Evaluation of cytotoxicity and MRI contrast enhancement ability of Fe3O4@PLA-PEG iron oxide nanoparticles in vitro model
نویسندگان
چکیده
SPIONs are composed of Fe3O4 or gamma Fe2O3 cores and a biocompatible shell from Dextran, PLA, PEG, Chitosan, PVA. have many important applications in medicine biology such as cell sorting, drug carrier, magnetic hyperthermia, resonance imaging (MRI). This study aims to check the ability copolymer PLA-PEG coated ferromagnetic nanosystems (Fe3O4@PLA-PEG) produced for MRI application. The results showed that these nanoparticles had non-toxicity on BT-474 Sarcoma 180 lines. Evaluation T2 mode revealed Fe3O4@PLA-PEG were capable enhancing image contrast different conditions, including water, lysates solution, even inside cells. report demonstrates high potential application clinical diagnosis.
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ژورنال
عنوان ژورنال: T?p chí Khoa h?c và Công ngh? Vi?t Nam
سال: 2021
ISSN: ['2615-9759', '2615-9929', '1859-4794']
DOI: https://doi.org/10.31276/vjst.63(8).30-34